Dutch Atherosclerosis Society

Prof. dr. J.W. Jukema, co-chairman 

Biography

Born : October-24-1962
Citizenship : Dutch
Marital Status : Married to Swanette R. Leenstra
Profession: Occupational Health Officer
3 children

Hospital :
Leiden University Medical Center (LUMC)
Professor of Cardiology
Head/Director Interventional Cardiology
Established Clinical Investigator Netherlands Heart Found.

Staff Dept. of Cardiology C5-P
P.O. Box 9600
2300 RC Leiden, the Netherlands
Phone: +31(71)5262020
Fax: +31(71)5266885
E-mail: j.w.jukema@lumc.nl

Education

1969 - 1975 : Primary School, Amersfoort, the Netherlands

1975 - 1981 : Secondary School, Gymnasium B, Amersfoort, the Netherlands

1981 - 1985 : Free University of Amsterdam, School of Medicine, the Netherlands
Graduation: Cum Laude

Professional Experience

1985 - 1986: Student-Research Associate, Department of Cardiology (Prof. F.W.A. Verheugt, MD, PhD), Free University of Amsterdam, the Netherlands

1986 - 1988: Student-Research Associate, Department of Pathology (Prof. J.P.A. Baak, MD, PhD), Free University of Amsterdam, the Netherlands

1985 - 1987: Rotating Internships, Free University of Amsterdam and affiliated hospitals, Haarlem, the Netherlands

Dec 1987: Graduation (MD), School of Medicine, Free University of Amsterdam, the Netherlands

1987 - 1990: Internal Medicine Residency (S.C.C. Reinders Folmer MD, PhD),  Spaarne Hospital Haarlem, the Netherlands

1990 - 1991: Fellowship Cardiology (H.H. Kruyswijk MD, PhD), Spaarne Hospital Haarlem, the Netherlands

1991 - 1993: Fellowship Cardiology (Prof. A.V.G. Bruschke, MD, PhD), University Hospital Leiden, the Netherlands

Dec 1990: Level IVa-exam on radiation protection, Sylvius Laboratory, Leiden, the Netherlands

Sept 1992: Course on quantitative coronary and left ventricular digital and cineangiography, Core Laboratory, University Hospital Leiden, Leiden, the Netherlands

Sept 1993: Registration as Cardiologist

1992 - 1994: Cardiac Catheterization Laboratory Staff Member (50%)
University Hospital Leiden, the Netherlands

1992 - 1994: Research Fellow in Cardiology (50%), Interuniversity Institute of Cardiology, (Prof. A.V.G. Bruschke, MD, PhD and Prof. H.J.J. Wellens, MD, PhD),
Utrecht, the Netherlands

Dec 1994 : Course on coronary stenting, Thoraxcenter, Erasmus University,
Rotterdam, the Netherlands

Oct 1995 : Postgraduate course on lipids, genetics and atherosclerosis, Academical Medical Center, University of Amsterdam, Amsterdam, the Netherlands

May 1996 : Doctoral Thesis (PhD) "Angiographic Coronary Atherosclerosis Trials: design, methodology, and results- focussing on the Regression Growth Evaluation Statin Study, 'REGRESS'". University of Leiden School of Medicine, Leiden, the Netherlands

Sept 1996 : Course on "improving clinical outcome in the high risk PTCA patient"
Cleveland Clinic, Cleveland, Ohio, U.S.A.

Nov - Dec 1996 : Fellowship provided by the European Society of Cardiology:"Atherosclerosis: nutrition, lipoproteins and genetic backgrounds"
Center for Clinical and Human Nutrition, University of Texas Southwestern Medical Center at Dallas, U.S.A. (Chairman and director: Prof. Scott M. Grundy, MD, PhD)

July 1997 : Rater of the ESC/ACC/NEMA cardiac image compression study.
Johannes Gutenberg University Clinic, Mainz, Germany

November 1999 : Course on "How to sell technology, all aspects of technology transfer by a research institute (Negotiations, Intellectual Property, Contractual Relations, Strategy and Organization, Worldwide Licensing)", provided by the Dutch Royal Academy of Sciences, Doorn, the Netherlands

Sept/Oct 2000 : Course on Higher Management, Leiden University Medical Center, NL

March 2001 : Appointment as Associate Professor of Cardiology, Leiden University, Leiden, NL

January 2002 : Appointment as Established Clincical Investigator, Netherlands Heart Foundation

Current professional functions

Staff Member Department of Cardiology, Professor of Cardiology, Head/director Interventional Cardiology, Leiden University Medical Center, Leiden, the Netherlands.

Established Clinical Investigator Netherlands Heart Foundation (2001D032)

Consulting cardiologist of the Heart Core Laboratory for cardiovascular clinical research trials, Leiden, the Netherlands.

Teacher/moderator in international physician training sessions for intra coronary-stenting procedures, guided by intra vascular ultrasound.

Teacher in sessions of the "peer eduction program on atherosclerosis " organized by Excerpta Medica; post graduate courses for general practitioners.

Organizer of and teacher in "postgraduate course on lipids, genetics and atherosclerosis and the implications of intervention trials" a joint project of the Academical Medical Center, University of Amsterdam and the Leiden University Medical Center, the Netherlands.

Teacher in weekly sessions of clinical cases for medical students and residents.

Teacher for biomedical science students, topic: "human coronary pathology".

Editor of Internet web-site on "angina pectoris, coronary artery disease and coronary circulation" provided by the Interuniversity Cardiology Institute of the Netherlands.

Organizer of and teacher in "molecular cardiology and atherosclerosis" course
under auspices of the Netherlands Institute for Continuing Cardiovascular Education.

Organizer of and teacher in "course on atherosclerosis" for Dutch cardiology fellows, under auspices of Cardiology Education Committee.

Member of the editorial board of: Netherlands Heart Journal
Acta Cardiologica

Current fields of research

Project manager of the REGRESS study (Regression Growth Evaluation Statin Study), a multicenter placebo controlled study to assess the effects of 2 year treatment with pravastatin on pro- and regression of angiographically documented coronary artery disease in 885 patients with a serum cholesterol between 4 and 8 mmol/l, using quantitative coronary angiography and B-mode ultrasound.
Large substudies include specialised lipid research and evaluation of genetic markers of the dynamics of coronary atherosclerosis. Study sponsors: Bristol Myers Squibb and the Interuniversity Cardiology Institute of the Netherlands (ICIN).

Principal investigator of the cardiac branch of the "Pancreas Transplantation Study", an international multicenter study to assess the success of combined kidney and pancreas transplantation. The cardiac branch of this study evaluates the effects of the transplantation on progression and regression of coronary artery disease assessed by quantitative coronary angiography.

Principal investigator of several animal model studies (ApoE3 Leiden transgenic mice) for studying behaviour of atherosclerosis and responses of atherosclerosis to various drug regimens by means of histological and immunological techniques. Furthermore vascular wall tissue constituents are studied by Raman spectroscopy. These studies are carried out in close cooperation with the T.N.O.-PG Gaubius Laboratory (Prof. L.M. Havekes, PhD, H.M.G. Princen, PhD). Sponsors: Pfizer and Ministery of Economics.

Investigator of atherosclerosis research protocols using Raman spectroscopy, a new promising technique that enables quantitative analysis of the chemical composition of the vascular wall. By illuminating the tissue with infrared laser light and collecting the light emitted from the tissue, highly molecule specific Raman spectra can be obtained. Cooperation with the Erasmus University Rotterdam the Netherlands, and the Massachusetts Institute of Technology (MIT), Cambridge, Mass, and the Cleveland Clinic Foundation, Cleveland, Ohio.

Investigator of research protocols evaluating endothelium dependent vasodilation in the forearm of patients with different kinds of dyslipidemia on different treatment modalities.

Participating investigator in several intra coronary stent trials combined with intra coronary ultrasound, currently focussing on long term effects of stent coatings, both in humans as well as in transgenic atherosclerotic mice.
(Established Clinical Investigator of the Netherlands Heart Foundation)

Investigator and Dutch coordinator of the TNT (Treat to New Targets) trial. An international multicenter double blind randomized trial, to study the effect of LDL-cholesterol lowering beyond currently recommended minimum targets on coronary heart disease recurrence in patients with pre-existing coronary heart disease. Patient are randomized to atorvastatin 10 mg or 80 mg. Clinical events will be evaluated in 8600 patients in five years follow-up time. This study is sponsored by Pfizer Int.

Investigator and member of the end point committee of the PROSPER trial (PROspective Study of Pravastatin in the Elderly at Risk). An international, three centre study, double blind randomized, to assess the efficacy of pravastatin to prevent stroke, myocardial infarction and cognitive impairment in 5500 elderly subjects. This study is sponsored by Bristol Myers Squibb Inc.

Investigator of a study to detect significant stenoses in saphenous bypass graft by magnetic resonance imaging (MRI), correlated to intra coronary Doppler flow and flow reserve assessments. This study is supported by the Netherlands Heart Foundation (grant 97.173).

Principal investigator a genetic studies which studies cholesteryl ester transfer protein (CETP) gene variation; an important factor in the response to lipid lowering therapy. This study is sponsored by the Netherlands Heart Foundation (grant 1998.163)

Principal investigator of the Genetic Determinants of Restenosis (GENDER) project. A multicenter study to investigate genetic aspects of restenosis after PTCA. This study is supported by a grants of the Interuniversity Cardiology Institute of the Netherlands (ICIN) and the Netherlands Heart Foundation (grant 99.210 ). The project has started in Feb. 1999.

Principal investigator for a genetics studies which develop methods for multilocus haplotypes and joint effects of genes for estimation of the risk of cardiovascular disease progression. This study is sponsored by the Netherlands Heart Foundation (grant 2000.125 ).

Investigator of Statin in Diabetics (LiDIA) study. A Dutch study to investigate the effects of cerivastatin on vascular morbidity, evaluated by forearm blood flow and 24 h ECG monitoring, in 250 type-2 diabetic patients.
This study is sponsored by Bayer AG/MSD.

Main investigator of the Prevention of re-Infarction with early treatment by Cerivastatin Study (PRINCESS). An international randomized placebo controlled study with cerivastatin early or 3 months after myocardial infarction.
The study is sponsored by Bayer AG.

Principle investigator of the comparison of Rosuvastatin and Atorvastatin in different Dosages and effects on Reversed cholesterol transport (RADAR) study. A Dutch study in 600 patients.
This study is sponsored by Astra Zeneca.

Principal investigator of the GREAT study "Genes of Restenosis Evaluated by Activity of Transcription ". Gene expression profiles of restenotic, atherosclerotic and normal vessel tissue are obtained by coronary atherectomy and compared. Gene expression profiles are generated using a custom-made micro-array including 4500cDNA clones. This study is sponsored by Guidant Inc.

Investigator on molecular imaging of corornary atherosclerosis (adhesion molecules, scavenger receptors).

Co-investigator in projects on modulation of gene-expression as therapy for atherosclerosis. Topics:
* New strategies (a.o. macrophage-specific photodynamic therapy) to eliminate (lipid laden) macrophages from the atherosclerotic plaque and evaluation of its therapeutic potential in atherosclerosis.
* Non-viral drug carriers for local prevention of restenosis after PTCA.
* Neoangiogenesis
Collaboration with Leiden/Amsterdam Center for Drug Research, division of Biopharmaceutics (Prof. Dr. Th. J.C. van Berkel) and the Free University of Amsterdam.

Awards

1996: 2nd price in "Best Cardiovascular PhD-Thesis in the Netherlands Contest".

1996: "Best clinical research article of the Leiden University Medical Center-NL Contest".

2001: "C.J. Kok Physics/Chemics/Molecular Biology Price". Award received at the
Leiden Univeristy Medical Center

2002: "Established Clincial Investigator" of the Netherlands Heart Foundation

Professional Societies/Committees

Member (1991) Dutch Society of Cardiology
Member (1991) European Society of Cardiology
Member (1992) Angiography Committee, Interuniversity Institute of Cardiology, Utrecht, the Netherlands
Fellow (1992) American College of Angiology (FACA)
Member (1994) Council on Arteriosclerosis, Thrombosis and Vascular Biology of the American Heart Association
Member (1994) International Atherosclerosis Society
Member (1995) Working Group Interventional Cardiology, Dutch Soc. of Cardiology
Member (1996) Dutch Working Group on Lipoproteins
Member (1996) Working Group on National Guidelines for Cardiovascular Risk Factors in Diabetes
Member (1996) Dutch Working Group on National Guidelines for Cholesterol
Member (1997) European Atherosclerosis
Member (1997) Working group on Dutch Interventional Cardiology
Fellow (1997) European Society of Cardiology (FESC)
Member (1999) Dutch Working Group on Vascular Cardiology
Fellow (2001) American College of Cardiology (FACC)
Member (2001) Nucleus of the European Society of Cardiology on pathogenesis of atherosclerosis
Member (2002) Board of Directors of the Foundation for Heriditary Hypercholesterolemaemia, the Netherlands
Member (2002) Board of Directors of the Dutch Atherosclerosis Society
Chairman (2007) of the Dutch Atherosclerosis Society


Chairman of Sessions of International Meetings

Berlin, Germany (1994) 12th World Congress of Cardiology,
16th Congress of the European Society of
Cardiology

Amsterdam, the Netherlands (1995) 17th Congress of the European Society of Cardiology

Maastricht, the Netherlands (1997) Congress of the European Federation of
Internal Medicine

Amsterdam, the Netherlands (2000) 22nd Congress of the European Society of Cardiology

Cairo, Egypt (2000) Golden Jubilee/International Meeting of the
Egyptian Society of Cardiology

Berlin, Germany (2002) 24th Congress of the European Society of Cardiology

Member of Scientific/Organizing Committees of International Meetings

17th Congress of the European Society of Cardiology, 1995, Amsterdam, the Netherlands.

1st International Congress on Angiogenesis, 1999, Amsterdam, the Netherlands, organized by Free University Medical Center, Leiden University Medical Center and TNO-PG, the Netherlands.

Master Classes in Atherosclerosis, 2000, under auspices of the European Society of Cardiology
University College, Cork, Ireland.

22nd Congress of the European Society of Cardiology, 2000, Amsterdam, the Netherlands.

23rd Congress of the European Society of Cardiology, 2001, Stockholm, Sweden.

24th Congress of the European Society of Cardiology, 2002, Berlin, Germany.

National Meetings

Organiser/member of scientific committee of numerous Dutch Courses/Conferences on Lipidologic and Genetic Ascpects of Atherosclerosis and Interventional Cardiology.