Dutch Atherosclerosis Society

Prof. dr. E.S.G. Stroes co-chairman 

Curriculum Vitae

Personal data:

Name: Stroes
First name: Erik Sjoerd Gerard
Date of birth: September 29, 1966
Place of birth: Leiden

Dept. of Vascular Medicine
Academic Medical Center
Meibergdreef 9
1105 AZ Amsterdam, The Netherlands
tel: +31 20 566 6612
fax: +31 20 566 9343

Education - Work History
1983-1990: University Training Medicine, Erasmus University Rotterdam
1990 Jan.: M.D. Medicine (cum Laude)
11-1990 - 11-1997: Specialization Internal Medicine, University Hospital Utrecht
3-1995 – 3-1996: Fellowship Nephrology, Dept Nephrology, University Hospital Utrecht
10-1996: Thesis “Mechanisms and Modulation of endothelial dysfunction in humans” (ISBN 90-393-1226-5)
1999-2001: Fellow Dept. of Internal Medicine, UMC Head: (late) Prof. Dr D.W. Erkelens
02-2001- present: Staff Vascular Medicine, AMC Head: Prof Dr J.J.P. Kastelein
2004: Head outpatient clinic Vascular Medicine


2001 Hanneke Wilmink: lipoproteins – vessel wall, UMC Utrecht
2005 Joris Rotmans: intimal proliferation shunts, AMC
2006 dec. Radjesh Bisoendial: CRP and HDL in atherogenesis, AMC
2006 dec. Melchior Nierman: HDL and Triglyceride metabolism, AMC
2007 march Raaj Sankatsing: HDL in HIV, AMC
2007 june Rakesh Birjmohun: HDL-c modulation, AMC
2007 june Max Nieuwdorp: Glycocalyx modulation, AMC
2008 Marijn Meuwese: myeloperoxidase and HDL, AMC
2008 Sander van Leuven: HDL in chronic infl. Disease, AMC
2008 Fatima Akdim: antisense strategies in humans, AMC

• Dekker fellowship Dutch heart foundation (1997) 200.000 ´Non-invasive assessment of vascular function´ (D97.0023) Evaluation DHF: excellent
• Program grant Dutch Kidney foundation (2000) 900.000 ´Gene therapeutic approaches to prevent dialysis graft failure´ (CSP 6001) Evaluation: Outstanding / cum Laude 
• EU-STREP AMC: 400.000 ‘Lipidomic profiles of HDL in subjects with Low and high HDL syndromes: and contribution of sex hormones to HDL levels (collaboration von Eckardstein, Rentsch, Spanaus)
• Dutch Heart Foundation 2006: 180.000 Role of Glycocalyx in vascular disease

• Future Forum Grant 2006 40.000 Reumatoid arthritis and cardiovascular disease
• Bayer Grant 2002: 50.000 Patient compliance optimization
• Pfizer grant 2003: 125.000 Intima media thickness and cardiovascular risk management (VITAL study)
• Pfizer grant 2004: 235.000 CRP and atherogenesis: lessons in humans.
• Aspreva grant 2005: 75.000 Role of MMF in atherogenesis: endarteriectomy study
• Boehringer Ingelheim grant 2005 (coll. P.Reiss): 600.000 Effect of nevaripine on HDL metabolism
• Roche grant 2006: 140.000 Impact of HDL functionality on clinical outcome

International collaborations:
1 Center for Mol. Therepeutics, Gene finding Vancouver, Canada, Prof M Hayden
2. University College London, UK, Non-invasive vascular function, Prof Dr J Deanfield 3. University Sydney, Australia HDL and inflammation, Prof Dr P Barter

National collaborations:
1. UMC Utrecht Vascular pathology (animal research), Prof G Pasterkamp
2. UMC Groningen Reverse cholesterol transport, Prof Dr F Kuipers
3. VU, Amsterdam Glycocalyx in diabetes, Prof RJ Heine

Local – AMC collaborations:
1. Pathology cellular plaque inflammation, AC van der Wal
2. Cardiology optimization of secondary prevention, Prof RJ Peters
3. Medical Physics Glycocalyx techniques, Dr H Vink

Other activities
• Clinic Head outpatient clinic Vascular Medicine, Supervising consultant thrombosis- haemostasis
Past: Vice-chair Internistisch Vasculair Genootschap (IVG) 
Present: Council Arteriosclerosis Vascular Biology, AHA; Board Member Dutch Atherosclerosis Society (DAS) 

12-1995: Annual Award of Scientific Research University Hospital Utrecht.
4-1998: Recipient of Annual Award of Cardiovascular Biology (Dutch Society of Cardiology)

Selected International Scientific Presentations:
1. "Short-term deterioration and improvement of forearm vascular function in hypercholesterolaemic patients off and on lipid-lowering therapy". 68th Scientific Sessions of the American Heart Association, United States of America, November 1995.
2. "Tetrahydrobiopterin ameliorates endothelial function in patients with familial hypercholesterolemia". 30th Annual Meeting of European Society of Clinical Investigation,
Interlaken, Switzerland, April 24-27, 1996.
3. "Cyclosporine-A induced increase in nitric oxide release counterbalances its vasoconstrictive effects. Second European Kidney Research Forum, Bergamo, Italy, May 24-27, 1996.
4. “Tetrahydrobiopterin restores endothelial function in hypercholesterolemia”. 69th Scientific Session of the American Heart Association, New Orleans, United States of America, November 1996.
5. “The role of the endothelium in the prevention of end-organ damage”. Groupe Recherche Systeme Nerves Autonomique, Montreal, Canada, December 3, 1998.
6. “Origin of superoxide release by endothelial nitric oxide synthase”. International Symposium on Vascular Protection, Los Angeles, USA, December 5-9, 1998.
7. “Renin angiotensin system in atherosclerosis. 8th international congress on cardiovascular pharmacotherapy, Amsterdam, The Netherlands, March 28 – April 1, 1999.
8. “Folic acid reverts NOS uncoupling”. American Heart Association, November 1999, USA.
9. “Sympathetic stimulation overrides flow mediated dilation”. American Heart Association, November 2000, USA.
10. “HDL restores endothelial dysfunction in hypoalfalipoproteinemia”. American Heart Association, November 2003, USA.
11. “CRP elicits inflammation and coagulation”. American heart Association, November 2004, USA
12. “LDL potentiates adverse effects of CRP in vivo in humans’. DALM, Venice, Italy, September 2004.
13. ‘Fibrate therapy in diabetic patients’. EASD, Athens, September 2005
14. ‘Low HDL predisposes to pro-inflammatory state in humans’. American heart association, November 2005
15. ‘Glycocalyx determines microvascular complications in type I diabetic patients’. American heart association, November 2005

Invited lectures:
1. ‘Role of HDL as anti-inflammatory agent in humans’ 2nd global meeting HDL research Greece, October 2004
2. ´HDL en atherogenese, nieuwe inzichten NHS wetenschapsdag 2005
3. ´Chronic inflammatory disease and atherogenesis´ University College London / Immunology update 2005
4. ´LDL / HDL balans en preventie van hart en vaatziekten IVG symposium, Zeist 2005
5. ´HDL as cornerstone for anti/atherosclerotic regimens´ 21st Ernst Klinikum symposium in Molecular Medicine Koln, Germany, december 2005
6. ´Novel targets for cardiovascular prevention´ International Society of Nephrology / Forefronts symposium New York, march 2006.
7. ‘Changing world of CV-prevention: Does HDL-increase still fit the picture?’ DAS symposium, Ede 2009

1: Sankatsing RR, Wit FW, Pakker N, Vyankandondera J, Mmiro F, Okong P, Kastelein
JJ, Lange JM, Stroes ES, Reiss P. Effects of Nevirapine, Compared with Lamivudine, on Lipids and Lipoproteins in HIV-1-Uninfected Newborns: The Stopping Infection from Mother-to-Child via Breast-Feeding in Africa Lipid Substudy. J Infect Dis. 2007 Jul 1;196(1):15-22. Epub 2007 May 16. PMID: 17538878 [PubMed - in process]
2: van Leuven SI, Stroes ES. Mannose-binding lectin and agalactosyl IgG and risk of ischemic heart disease in rheumatoid arthritis: Comment on the article by Troelsen et al. Arthritis Rheum. 2007 May 25;56(6):2097 [Epub ahead of print] No abstract available. PMID: 17530653 [PubMed - as supplied by publisher]
3: van der Steeg WA, Boekholdt SM, Stein EA, El-Harchaoui K, Stroes ES, Sandhu MS, Wareham NJ, Jukema JW, Luben R, Zwinderman AH, Kastelein JJ, Khaw KT. Role of the apolipoprotein B-apolipoprotein A-I ratio in cardiovascular risk assessment: a case-control analysis in EPIC-Norfolk. Ann Intern Med. 2007 May 1;146(9):640-8. PMID: 17470832 [PubMed - indexed for MEDLINE]
4: Akdim F, van Leuven SI, Kastelein JJ, Stroes ES. Pleiotropic effects of statins: stabilization of the vulnerable atherosclerotic plaque? Curr Pharm Des. 2007;13(10):1003-12. Review.
PMID: 17430164 [PubMed - indexed for MEDLINE]
5: Van Teeffelen JW, Brands J, Stroes ES, Vink H. Endothelial glycocalyx: sweet shield of blood vessels. Trends Cardiovasc Med. 2007 Apr;17(3):101-5. PMID: 17418372 [PubMed - in process]
6: Nieuwdorp M, Holleman F, de Groot E, Vink H, Gort J, Kontush A, Chapman MJ, Hutten BA, Brouwer CB, Hoekstra JB, Kastelein JJ, Stroes ES. Perturbation of hyaluronan metabolism predisposes patients with type 1 diabetes mellitus to atherosclerosis. Diabetologia. 2007 Jun;50(6):1288-93. Epub 2007 Apr 6. PMID: 17415544 [PubMed - in process]
7: van den Berg BM, Nieuwdorp M, Stroes ES, Vink H. Glycocalyx and endothelial (dys) function: from mice to men. Pharmacol Rep. 2006;58 Suppl:75-80. PMID: 17332675 [PubMed - in process]
8: Birjmohun RS, van Leuven SI, Levels JH, van 't Veer C, Kuivenhoven JA, Meijers JC, Levi M, Kastelein JJ, van der Poll T, Stroes ES. High-density lipoprotein attenuates inflammation and coagulation response on endotoxin challenge in humans. Arterioscler Thromb Vasc Biol. 2007 May;27(5):1153-8. Epub 2007 Feb 15. PMID: 17303780 [PubMed - indexed for MEDLINE]
9: Monajemi H, Zhang L, Li G, Jeninga EH, Cao H, Maas M, Brouwer CB, Kalkhoven E,
Stroes E, Hegele RA, Leff T. Familial partial lipodystrophy phenotype resulting from a single-base mutation in deoxyribonucleic acid-binding domain of peroxisome proliferator-activated receptor-gamma. J Clin Endocrinol Metab. 2007 May;92(5):1606-12. Epub 2007 Feb 13. PMID: 17299075 [PubMed - indexed for MEDLINE]
10: El Harchaoui K, van der Steeg WA, Stroes ES, Kuivenhoven JA, Otvos JD, Wareham NJ, Hutten BA, Kastelein JJ, Khaw KT, Boekholdt SM. Value of low-density lipoprotein particle number and size as predictors of coronary artery disease in apparently healthy men and women: the EPIC-Norfolk Prospective Population Study. J Am Coll Cardiol. 2007 Feb 6;49(5):547-53. Epub 2007 Jan 22. PMID: 17276177 [PubMed - indexed for MEDLINE]
11: Bisoendial RJ, Kastelein JJ, Peters SL, Levels JH, Birjmohun R, Rotmans JI, Hartman D, Meijers JC, Levi M, Stroes ES. Effects of CRP infusion on endothelial function and coagulation in normocholesterolemic and hypercholesterolemic subjects. J Lipid Res. 2007 Apr;48(4):952-60. Epub 2007 Jan 26. PMID: 17259597 [PubMed - in process]
12: Rotmans JI, Heyligers JM, Stroes ES, Pasterkamp G. Endothelial progenitor cell-seeded grafts: rash and risky. Can J Cardiol. 2006 Nov;22(13):1113-6. Review. PMID: 17102827 [PubMed - indexed for MEDLINE]
13: Birjmohun RS, van der Steeg WA, Stroes ES, Kastelein JJ. [The role of the high-density lipoprotein (HDL) particle in atherogenesis and potential methods to increase HDL concentrations] Ned Tijdschr Geneeskd. 2006 Oct 14;150(41):2245-50. Review. Dutch. PMID: 17076358 [PubMed - indexed for MEDLINE]
14: Nierman MC, Rip J, Kuivenhoven JA, Sakai N, Kastelein JJ, de Sain-van der Velden MG, Stroes ES, Prinsen BH. Enhanced apoB48 metabolism in lipoprotein lipase X447 homozygotes.
Atherosclerosis. 2006 Sep 19; [Epub ahead of print] PMID: 16989840 [PubMed - as supplied by publisher]
15: Rotmans JI, Heyligers JM, Stroes ES, Pasterkamp G. Endothelial progenitor cell-seeded grafts: rash and risky. Can J Cardiol. 2006 Sep;22(11):929-32. Review. PMID: 16971977 [PubMed - indexed for MEDLINE]
16: Keller TT, van Leuven SI, Meuwese MC, Wareham NJ, Luben R, Stroes ES, Hack CE, Levi M, Khaw KT, Boekholdt SM. Serum levels of mannose-binding lectin and the risk of future coronary artery disease in apparently healthy men and women. Arterioscler Thromb Vasc Biol. 2006 Oct;26(10):2345-50. Epub 2006 Aug 10. PMID: 16902159 [PubMed - indexed for MEDLINE]
17: Meuwese MC, Franssen R, Stroes ES, Kastelein JJ. And then there were acyl coenzyme A:cholesterol acyl transferase inhibitors. Curr Opin Lipidol. 2006 Aug;17(4):426-30. Review.
PMID: 16832167 [PubMed - indexed for MEDLINE]
18: van Leuven SI, Kastelein JJ, D'Cruz DP, Hughes GR, Stroes ES. Atherogenesis in rheumatology. Lupus. 2006;15(3):117-21. Review. PMID: 16634362 [PubMed - indexed for MEDLINE]
19: Gouverneur M, Berg B, Nieuwdorp M, Stroes E, Vink H. Vasculoprotective properties of the endothelial glycocalyx: effects of fluid shear stress. J Intern Med. 2006 Apr;259(4):393-400. Review. PMID: 16594907 [PubMed - indexed for MEDLINE]
20: Rip J, Nierman MC, Ross CJ, Jukema JW, Hayden MR, Kastelein JJ, Stroes ES, Kuivenhoven JA. Lipoprotein lipase S447X: a naturally occurring gain-of-function mutation.
Arterioscler Thromb Vasc Biol. 2006 Jun;26(6):1236-45. Epub 2006 Mar 30. Review. PMID: 16574898 [PubMed - indexed for MEDLINE]
21: Nieuwdorp M, Mooij HL, Kroon J, Atasever B, Spaan JA, Ince C, Holleman F, Diamant M, Heine RJ, Hoekstra JB, Kastelein JJ, Stroes ES, Vink H. Endothelial glycocalyx damage coincides with microalbuminuria in type 1 diabetes. Diabetes. 2006 Apr;55(4):1127-32. PMID: 16567538 [PubMed - indexed for MEDLINE]
22: Nieuwdorp M, van Haeften TW, Gouverneur MC, Mooij HL, van Lieshout MH, Levi M, Meijers JC, Holleman F, Hoekstra JB, Vink H, Kastelein JJ, Stroes ES. Loss of endothelial glycocalyx during acute hyperglycemia coincides with endothelial dysfunction and coagulation activation in vivo. Diabetes. 2006 Feb;55(2):480-6. PMID: 16443784 [PubMed - indexed for MEDLINE]
23: Klerkx AH, El Harchaoui K, van der Steeg WA, Boekholdt SM, Stroes ES, Kastelein JJ, Kuivenhoven JA. Cholesteryl ester transfer protein (CETP) inhibition beyond raising high-density lipoprotein cholesterol levels: pathways by which modulation of CETP activity may
alter atherogenesis. Arterioscler Thromb Vasc Biol. 2006 Apr;26(4):706-15. Epub 2006 Jan 26. Review. PMID: 16439711 [PubMed - indexed for MEDLINE]
24: Bisoendial R, Birjmohun R, Keller T, van Leuven S, Levels H, Levi M, Kastelein J, Stroes E.
In vivo effects of C-reactive protein (CRP)-infusion into humans. Circ Res. 2005 Dec 9;97(12):e115-6. No abstract available. PMID: 16339489 [PubMed - indexed for MEDLINE]
25: van Leuven SI, Kastelein JJ, Allison AC, Hayden MR, Stroes ES. Mycophenolate mofetil (MMF): firing at the atherosclerotic plaque from different angles? Cardiovasc Res. 2006 Feb 1;69(2):341-7. Epub 2005 Nov 10. Review. PMID: 16289002 [PubMed - indexed for MEDLINE]
26: Rip J, Nierman MC, Sierts JA, Petersen W, Van den Oever K, Van Raalte D, Ross CJ, Hayden MR, Bakker AC, Dijkhuizen P, Hermens WT, Twisk J, Stroes E, Kastelein JJ, Kuivenhoven JA, Meulenberg JM. Gene therapy for lipoprotein lipase deficiency: working toward clinical application. Hum Gene Ther. 2005 Nov;16(11):1276-86. PMID: 16259561 [PubMed - indexed for MEDLINE]
27: Nierman MC, Rip J, Kuivenhoven JA, van Raalte DH, Hutten BA, Sakai N, Kastelein JJ, Stroes ES. Carriers of the frequent lipoprotein lipase S447X variant exhibit enhanced
postprandial apoprotein B-48 clearance. Metabolism. 2005 Nov;54(11):1499-503. PMID: 16253639 [PubMed - indexed for MEDLINE]
28: Bisoendial R, Kastelein J, Stroes E. In response to van den Berg et al: on the direct actions of CRP in humans. Circ Res. 2005 Sep 30;97(7):e71. No abstract available. PMID: 16195481 [PubMed - indexed for MEDLINE]
29: Nierman MC, Prinsen BH, Rip J, Veldman RJ, Kuivenhoven JA, Kastelein JJ, de Sain-van der Velden MG, Stroes ES. Enhanced conversion of triglyceride-rich lipoproteins and increased low-density lipoprotein removal in LPLS447X carriers. Arterioscler Thromb Vasc Biol. 2005 Nov;25(11):2410-5. Epub 2005 Sep 29. PMID: 16195478 [PubMed - indexed for MEDLINE]
30: Rotmans JI, Stroes ES, Pasterkamp G. Letter regarding article by Luo et al, "Adenovirus-mediated expression of beta-adrenergic receptor kinase C-terminus reduces intimal hyperplasia and luminal stenosis of arteriovenous polytetrafluoroethylene grafts in pigs". Circulation. 2005 Sep 20;112(12):e153; author reply e153. No abstract available. PMID: 16172278 [PubMed - indexed for MEDLINE]
31: Nieuwdorp M, Meuwese MC, Vink H, Hoekstra JB, Kastelein JJ, Stroes ES. The endothelial glycocalyx: a potential barrier between health and vascular disease. Curr Opin Lipidol. 2005 Oct;16(5):507-11. Review. PMID: 16148534 [PubMed - in process]
32: van Leuven SI, Kastelein JJ, Hayden MR, d'Cruz D, Hughes GR, Stroes ES. Cardiovascular disease in systemic lupus erythematosus: has the time for action come? Curr Opin Lipidol. 2005 Oct;16(5):501-6. Review. PMID: 16148533 [PubMed - in process]
33: Stroes E. Statins and LDL-cholesterol lowering: an overview. Curr Med Res Opin. 2005;21 Suppl 6:S9-16. Review. PMID: 16138936 [PubMed - indexed for MEDLINE]
34: Bisoendial RJ, Hovingh GK, El Harchaoui K, Levels JH, Tsimikas S, Pu K, Zwinderman AE, Kuivenhoven JA, Kastelein JJ, Stroes ES. Consequences of cholesteryl ester transfer protein inhibition in patients with familial hypoalphalipoproteinemia. Arterioscler Thromb Vasc Biol. 2005 Sep;25(9):e133-4. No abstract available. PMID: 16127020 [PubMed - indexed for MEDLINE]
35: Sankatsing RR, Fouchier SW, de Haan S, Hutten BA, de Groot E, Kastelein JJ, Stroes ES.
Hepatic and cardiovascular consequences of familial hypobetalipoproteinemia. Arterioscler Thromb Vasc Biol. 2005 Sep;25(9):1979-84. Epub 2005 Jul 7. PMID: 16002743 [PubMed - indexed for MEDLINE]
36: Sankatsing RR, de Groot E, Jukema JW, de Feyter PJ, Pennell DJ, Schoenhagen P, Nissen SE, Stroes ES, Kastelein JJ. Surrogate markers for atherosclerotic disease. Curr Opin Lipidol. 2005 Aug;16(4):434-41. Review. PMID: 15990593 [PubMed - indexed for MEDLINE]
37: Rotmans JI, Heyligers JM, Verhagen HJ, Velema E, Nagtegaal MM, de Kleijn DP, de Groot FG, Stroes ES, Pasterkamp G. In vivo cell seeding with anti-CD34 antibodies successfully accelerates endothelialization but stimulates intimal hyperplasia in porcine arteriovenous
expanded polytetrafluoroethylene grafts. Circulation. 2005 Jul 5;112(1):12-8. Epub 2005 Jun 27.
PMID: 15983250 [PubMed - indexed for MEDLINE]
38: Rotmans JI, Pattynama PM, Verhagen HJ, Hino I, Velema E, Pasterkamp G, Stroes ES.
Sirolimus-eluting stents to abolish intimal hyperplasia and improve flow in porcine arteriovenous grafts: a 4-week follow-up study. Circulation. 2005 Mar 29;111(12):1537-42. Epub 2005 Mar 21.
PMID: 15781738 [PubMed - indexed for MEDLINE]
39: Nieuwdorp M, Stroes ES, Meijers JC, Buller H. Hypercoagulability in the metabolic syndrome. Curr Opin Pharmacol. 2005 Apr;5(2):155-9. Review. PMID: 15780824 [PubMed - indexed for MEDLINE]
40: Bisoendial RJ, Kastelein JJ, Levels JH, Zwaginga JJ, van den Bogaard B, Reitsma PH, Meijers JC, Hartman D, Levi M, Stroes ES. Activation of inflammation and coagulation after infusion of C-reactive protein in humans. Circ Res. 2005 Apr 15;96(7):714-6. Epub 2005 Mar 17.
PMID: 15774855 [PubMed - indexed for MEDLINE]
41: Rotmans JI, Pasterkamp G, Verhagen HJ, Pattynama PM, Blankestijn PJ, Stroes ES.
Hemodialysis access graft failure: time to revisit an unmet clinical need? J Nephrol. 2005 Jan-Feb;18(1):9-20. Review. PMID: 15772918 [PubMed - indexed for MEDLINE]
42: Nierman MC, Rip J, Twisk J, Meulenberg JJ, Kastelein JJ, Stroes ES, Kuivenhoven JA.
Gene therapy for genetic lipoprotein lipase deficiency: from promise to practice. Neth J Med. 2005 Jan;63(1):14-9. Review. PMID: 15719847 [PubMed - indexed for MEDLINE]
43: Birjmohun RS, Hutten BA, Kastelein JJ, Stroes ES. Efficacy and safety of high-density lipoprotein cholesterol-increasing compounds: a meta-analysis of randomized controlled trials.
J Am Coll Cardiol. 2005 Jan 18;45(2):185-97. PMID: 15653014 [PubMed - indexed for MEDLINE]
44: Birjmohun RS, Hutten BA, Kastelein JJ, Stroes ES. Increasing HDL cholesterol with extended-release nicotinic acid: from promise to practice. Neth J Med. 2004 Jul-Aug;62(7):229-34. Review. PMID: 15554597 [PubMed - indexed for MEDLINE]
45: van Leth F, Phanuphak P, Stroes E, Gazzard B, Cahn P, Raffi F, Wood R, Bloch M, Katlama C, Kastelein JJ, Schechter M, Murphy RL, Horban A, Hall DB, Lange JM, Reiss P. Nevirapine and efavirenz elicit different changes in lipid profiles in antiretroviral-therapy-naive patients infected with HIV-1. PLoS Med. 2004 Oct;1(1):e19. Epub 2004 Oct 19. Erratum in: PLoS Med. 2004 Dec;1(3):e73. PMID: 15526045 [PubMed - indexed for MEDLINE]
46: Hovingh GK, Brownlie A, Bisoendial RJ, Dube MP, Levels JH, Petersen W, Dullaart RP, Stroes ES, Zwinderman AH, de Groot E, Hayden MR, Kuivenhoven JA, Kastelein JJ. A novel apoA-I mutation (L178P) leads to endothelial dysfunction, increased arterial wall thickness, and premature coronary artery disease. J Am Coll Cardiol. 2004 Oct 6;44(7):1429-35. PMID: 15464323 [PubMed - indexed for MEDLINE]
47: de Grooth GJ, Klerkx AH, Stroes ES, Stalenhoef AF, Kastelein JJ, Kuivenhoven JA. A review of CETP and its relation to atherosclerosis. J Lipid Res. 2004 Nov;45(11):1967-74. Epub 2004 Sep 1. Review. PMID: 15342674 [PubMed - indexed for MEDLINE]
48: Fruchart JC, Nierman MC, Stroes ES, Kastelein JJ, Duriez P. New risk factors for atherosclerosis and patient risk assessment. Circulation. 2004 Jun 15;109(23 Suppl 1):III15-9. Review. PMID: 15198961 [PubMed - indexed for MEDLINE]
49: Rotmans JI, Verhagen HJ, Velema E, de Kleijn DP, van den Heuvel M, Kastelein JJ, Pasterkamp G, Stroes ES. Local overexpression of C-type natriuretic peptide ameliorates vascular
adaptation of porcine hemodialysis grafts. Kidney Int. 2004 May;65(5):1897-905. PMID: 15086933 [PubMed - indexed for MEDLINE]
50: Kastelein JJ, Stroes ES, de Groot E. Subclinical atherosclerosis as a target of therapy: potential role of statins. Am J Cardiol. 2004 Mar 15;93(6):737-40. Review. No abstract available.
PMID: 15019880 [PubMed - indexed for MEDLINE]
51: Rotmans JI, Velema E, Verhagen HJ, Blankensteijn JD, de Kleijn DP, Stroes ES, Pasterkamp G. Matrix metalloproteinase inhibition reduces intimal hyperplasia in a porcine
arteriovenous-graft model. J Vasc Surg. 2004 Feb;39(2):432-9. PMID: 14743149 [PubMed - indexed for MEDLINE]
52: de Jongh S, Vissers MN, Rol P, Bakker HD, Kastelein JJ, Stroes ES. Plant sterols lower LDL cholesterol without improving endothelial function in prepubertal children with familial hypercholesterolaemia. J Inherit Metab Dis. 2003;26(4):343-51. PMID: 12971422 [PubMed - indexed for MEDLINE]
53: Rotmans JI, Velema E, Verhagen HJ, Blankensteijn JD, Kastelein JJ, de Kleijn DP, Yo M, Pasterkamp G, Stroes ES. Rapid, arteriovenous graft failure due to intimal hyperplasia: a porcine,
bilateral, carotid arteriovenous graft model. J Surg Res. 2003 Jul;113(1):161-71. PMID: 12943826 [PubMed - indexed for MEDLINE]
54: Bisoendial RJ, Hovingh GK, Levels JH, Lerch PG, Andresen I, Hayden MR, Kastelein JJ, Stroes ES. Restoration of endothelial function by increasing high-density lipoprotein in subjects with isolated low high-density lipoprotein. Circulation. 2003 Jun 17;107(23):2944-8. Epub 2003 May 27. PMID: 12771001 [PubMed - indexed for MEDLINE]
55: Lilien MR, Stroes ES, Op't Roodt J, de Jongh S, Schroder CH, Koomans HA. Vascular function in children after renal transplantation. Am J Kidney Dis. 2003 Mar;41(3):684-91. PMID: 12612994 [PubMed - indexed for MEDLINE]
56: de Jongh S, Lilien MR, op't Roodt J, Stroes ES, Bakker HD, Kastelein JJ. Early statin therapy restores endothelial function in children with familial hypercholesterolemia. J Am Coll Cardiol. 2002 Dec 18;40(12):2117-21. PMID: 12505222 [PubMed - indexed for MEDLINE]
57: Bisoendial RJ, Hovingh GK, de Groot E, Kastelein JJ, Lansberg PJ, Stroes ES. Measurement of subclinical atherosclerosis: beyond risk factor assessment. Curr Opin Lipidol. 2002 Dec;13(6):595-603. Review. PMID: 12441883 [PubMed - indexed for MEDLINE]
58: de Jongh S, Lilien MR, Bakker HD, Hutten BA, Kastelein JJ, Stroes ES. Family history of cardiovascular events and endothelial dysfunction in children with familial hypercholesterolemia.
Atherosclerosis. 2002 Jul;163(1):193-7. PMID: 12048139 [PubMed - indexed for MEDLINE]
59: Diercks GF, Stroes ES, van Boven AJ, van Roon AM, Hillege HL, de Jong PE, Smit AJ, Gans RO, Crijns HJ, Rabelink TJ, van Gilst WH. Urinary albumin excretion is related to cardiovascular risk indicators, not to flow-mediated vasodilation, in apparently healthy subjects.
Atherosclerosis. 2002 Jul;163(1):121-6. PMID: 12048129 [PubMed - indexed for MEDLINE]
60: van Etten RW, de Koning EJ, Honing ML, Stroes ES, Gaillard CA, Rabelink TJ. Intensive lipid lowering by statin therapy does not improve vasoreactivity in patients with type 2 diabetes.
Arterioscler Thromb Vasc Biol. 2002 May 1;22(5):799-804. PMID: 12006393 [PubMed - indexed for MEDLINE]
61: Diercks GF, Stroes ES, Van Boven AJ, Van Roon AM, Hillege HL, De Jong PE, Smit AJ, Gans RO, Crijns HJ, Rabelink TJ, Van Gilst WH. Difference in the relation between urinary albumin excretion and carotid intima-media thickness in nondiabetic and type 2 diabetic subjects.
Diabetes Care. 2002 May;25(5):936-7. No abstract available. PMID: 11978696 [PubMed - indexed for MEDLINE]
62: Rooyakkers TM, Stroes ES, Kooistra MP, van Faassen EE, Hider RC, Rabelink TJ, Marx JJ. Ferric saccharate induces oxygen radical stress and endothelial dysfunction in vivo. Eur J Clin Invest. 2002 Mar;32 Suppl 1:9-16. PMID: 11886426 [PubMed - indexed for MEDLINE]
63: Hijmering ML, Stroes ES, Olijhoek J, Hutten BA, Blankestijn PJ, Rabelink TJ. Sympathetic activation markedly reduces endothelium-dependent, flow-mediated vasodilation. J Am Coll Cardiol. 2002 Feb 20;39(4):683-8. PMID: 11849869 [PubMed - indexed for MEDLINE]
64: Monnink SH, van Haelst PL, van Boven AJ, Stroes ES, Tio RA, Plokker TW, Smit AJ, Veeger NJ, Crijns HJ, van Gilst WH. Endothelial dysfunction in patients with coronary artery disease: a comparison of three frequently reported tests. J Investig Med. 2002 Jan;50(1):19-24.
PMID: 11820226 [PubMed - indexed for MEDLINE]
65: Verhaar MC, Stroes E, Rabelink TJ. Folates and cardiovascular disease. Arterioscler Thromb Vasc Biol. 2002 Jan;22(1):6-13. Review. PMID: 11788454 [PubMed - indexed for MEDLINE]
66: Attia DM, Verhagen AM, Stroes ES, van Faassen EE, Grone HJ, De Kimpe SJ, Koomans HA, Braam B, Joles JA. Vitamin E alleviates renal injury, but not hypertension, during chronic nitric
oxide synthase inhibition in rats. J Am Soc Nephrol. 2001 Dec;12(12):2585-93. PMID: 11729226 [PubMed - indexed for MEDLINE]
67: Hijmering ML, Stroes ES, Pasterkamp G, Sierevogel M, Banga JD, Rabelink TJ. Variability of flow mediated dilation: consequences for clinical application. Atherosclerosis. 2001 Aug;157(2):369-73. PMID: 11472736 [PubMed - indexed for MEDLINE]
68: Wilmink HW, Twickler MB, Banga JD, Dallinga-Thie GM, Eeltink H, Erkelens DW, Rabelink TJ, Stroes ES. Effect of statin versus fibrate on postprandial endothelial dysfunction: role of remnant-like particles. Cardiovasc Res. 2001 Jun;50(3):577-82. PMID: 11376633 [PubMed - indexed for MEDLINE]
69: Vanin AF, Huisman A, Stroes ES, de Ruijter-Heijstek FC, Rabelink TJ, van Faassen EE.
Antioxidant capacity of mononitrosyl-iron-dithiocarbamate complexes: implications for NO trapping. Free Radic Biol Med. 2001 Apr 15;30(8):813-24. PMID: 11295524 [PubMed - indexed for MEDLINE]
70: Sikkema JM, van Rijn BB, Franx A, Bruinse HW, de Roos R, Stroes ES, van Faassen EE.
Placental superoxide is increased in pre-eclampsia. Placenta. 2001 Apr;22(4):304-8. PMID: 11286565 [PubMed - indexed for MEDLINE]
71: Rabelink TJ, Stroes E. Atherosclerosis: defeat of the defense? Circ Res. 2001 Mar 16;88(5):456-7. No abstract available. PMID: 11249866 [PubMed - indexed for MEDLINE]
72: van Ampting JM, Hijmering ML, Beutler JJ, van Etten RE, Koomans HA, Rabelink TJ, Stroes ES. Vascular Effects of ACE Inhibition Independent of the Renin-Angiotensin System in
Hypertensive Renovascular Disease : A Randomized, Double-Blind, Crossover Trial. . 2001 Jan;37(1):40-45. PMID: 11208754 [PubMed - as supplied by publisher]
73: Stroes ES, van Faassen EE, Yo M, Martasek P, Boer P, Govers R, Rabelink TJ. Folic acid reverts dysfunction of endothelial nitric oxide synthase. Circ Res. 2000 Jun 9;86(11):1129-34.
PMID: 10850963 [PubMed - indexed for MEDLINE]
74: Wilmink HW, Stroes ES, Erkelens WD, Gerritsen WB, Wever R, Banga JD, Rabelink TJ.
Influence of folic acid on postprandial endothelial dysfunction. Arterioscler Thromb Vasc Biol. 2000 Jan;20(1):185-8. PMID: 10634816 [PubMed - indexed for MEDLINE]
75: Joles JA, Stroes ES, Rabelink TJ. Endothelial function in proteinuric renal disease.
Kidney Int Suppl. 1999 Jul;71:S57-61. Review. PMID: 10412739 [PubMed - indexed for MEDLINE]
76: Wilmink HW, Banga JD, Hijmering M, Erkelens WD, Stroes ES, Rabelink TJ. Effect of angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor antagonism on postprandial endothelial function. J Am Coll Cardiol. 1999 Jul;34(1):140-5. PMID: 10400003 [PubMed - indexed for MEDLINE]
77: Wever R, Boer P, Hijmering M, Stroes E, Verhaar M, Kastelein J, Versluis K, Lagerwerf F, van Rijn H, Koomans H, Rabelink T. Nitric oxide production is reduced in patients with chronic renal failure. Arterioscler Thromb Vasc Biol. 1999 May;19(5):1168-72. PMID: 10323766 [PubMed - indexed for MEDLINE]
78: Dijkhorst-Oei LT, Stroes ES, Koomans HA, Rabelink TJ. Acute simultaneous stimulation of nitric oxide and oxygen radicals by angiotensin II in humans in vivo. J Cardiovasc Pharmacol. 1999 Mar;33(3):420-4. PMID: 10069678 [PubMed - indexed for MEDLINE]
79: Vuong TD, Stroes ES, Willekes-Koolschijn N, Rabelink TJ, Koomans HA, Joles JA.
Hypoalbuminemia increases lysophosphatidylcholine in low-density lipoprotein of normocholesterolemic subjects. Kidney Int. 1999 Mar;55(3):1005-10. PMID: 10027937 [PubMed - indexed for MEDLINE]
80: Dijkhorst-Oei LT, Beutler JJ, Stroes ES, Koomans HA, Rabelink TJ. Divergent effects of ACE-inhibition and calcium channel blockade on NO-activity in systemic and renal circulation in essential hypertension. Cardiovasc Res. 1998 Nov;40(2):402-9. PMID: 9893735 [PubMed - indexed for MEDLINE]
81: Stroes ES, van Faassen EE, van Londen GJ, Rabelink TJ. Oxygen radical stress in vascular disease: the role of endothelial nitric oxide synthase. J Cardiovasc Pharmacol. 1998;32 Suppl 3:S14-21. Review. PMID: 9883742 [PubMed - indexed for MEDLINE]
82: Rabelink TJ, Stroes ES, Bouter KP, Morrison P. Endothelin blockers and renal protection: a new strategy to prevent end-organ damage in cardiovascular disease? Cardiovasc Res. 1998 Sep;39(3):543-9. Review. No abstract available. PMID: 9861295 [PubMed - indexed for MEDLINE]
83: Stroes E, Hijmering M, van Zandvoort M, Wever R, Rabelink TJ, van Faassen EE. Origin of superoxide production by endothelial nitric oxide synthase. FEBS Lett. 1998 Nov 6;438(3):161-4.
PMID: 9827538 [PubMed - indexed for MEDLINE]
84: Stroes ES, Rabelink TJ, Van Faassen EE. Redox state and health: a persisting challenge. Eur J Clin Invest. 1998 Nov;28(11):884-5. Review. No abstract available. PMID: 9824429 [PubMed - indexed for MEDLINE]
85: Honing ML, Morrison PJ, Banga JD, Stroes ES, Rabelink TJ. Nitric oxide availability in diabetes mellitus. Diabetes Metab Rev. 1998 Sep;14(3):241-9. Review. PMID: 9816472 [PubMed - indexed for MEDLINE]
86: Wever R, Stroes E, Rabelink TJ. Nitric oxide and hypercholesterolemia: a matter of oxidation and reduction? Atherosclerosis. 1998 Apr;137 Suppl:S51-60. Review. No abstract available. PMID: 9694542 [PubMed - indexed for MEDLINE]
87: Stroes E, de Bruin T, de Valk H, Erkelens W, Banga JD, van Rijn H, Koomans H,
Rabelink T. NO activity in familial combined hyperlipidemia: potential role of cholesterol
remnants. Cardiovasc Res. 1997 Dec;36(3):445-52. PMID: 9534865 [PubMed - indexed for MEDLINE]
88: Stroes ES, Luscher TF, de Groot FG, Koomans HA, Rabelink TJ. Cyclosporin A increases nitric oxide activity in vivo. Hypertension. 1997 Feb;29(2):570-5. PMID: 9040440 [PubMed - indexed for MEDLINE]
89: Stroes E, Kastelein J, Cosentino F, Erkelens W, Wever R, Koomans H, Luscher T, Rabelink T. Tetrahydrobiopterin restores endothelial function in hypercholesterolemia. J Clin Invest. 1997 Jan 1;99(1):41-6. PMID: 9011574 [PubMed - indexed for MEDLINE]
90: Rabelink TJ, Kaasjager KA, Stroes ES, Koomans HA. Endothelin in renal pathophysiology: from experimental to therapeutic application. Kidney Int. 1996 Dec;50(6):1827-33. Review. No abstract available. PMID: 8943463 [PubMed - indexed for MEDLINE]
91: Rabelink TJ, Stroes ES, Koomans HA. Mechanisms of cardiovascular injury in renal disease.
Blood Purif. 1996;14(1):67-74. Review. PMID: 8718568 [PubMed - indexed for MEDLINE]
92: Stroes ES, Koomans HA, de Bruin TW, Rabelink TJ. Vascular function in the forearm of hypercholesterolaemic patients off and on lipid-lowering medication. Lancet. 1995 Aug 19;346(8973):467-71. PMID: 7637480 [PubMed - indexed for MEDLINE]
93: Stroes ES, Joles JA, Chang PC, Koomans HA, Rabelink TJ. Impaired endothelial function in patients with nephrotic range proteinuria. Kidney Int. 1995 Aug;48(2):544-50. PMID: 7564124 [PubMed - indexed for MEDLINE]
94: Rabelink TJ, Kaasjager KA, Boer P, Stroes EG, Braam B, Koomans HA. Effects of endothelin-1 on renal function in humans: implications for physiology and pathophysiology.
Kidney Int. 1994 Aug;46(2):376-81. PMID: 7967349 [PubMed - indexed for MEDLINE]
95: Stehouwer CD, Stroes ES, Hackeng WH, Mulder PG, Den Ottolander GJ. von Willebrand factor and development of diabetic nephropathy in IDDM. Diabetes. 1991 Aug;40(8):971-6. Erratum in: Diabetes 1991 Dec;40(12):1746. PMID: 1907250 [PubMed - indexed for MEDLINE]
96: Oei HD, Stroes ES, Beukema WP, van der Zwan JC. [When can desensitization with bee and wasp venom be stopped?] Ned Tijdschr Geneeskd. 1991 Apr 20;135(16):719-20. Dutch. No abstract available. PMID: 2038399 [PubMed - indexed for MEDLINE]

Book (chapters):
Stroes ESG, Rabelink TJ. Hyperlipidemia and endothelial function. In : New Horizons in Vascular Endothelium. Editors: G Borne and C Schwartz. Schattauer Verlag 1997. Stroes ESG, Rabelink TJ. Endothelial dysfunction in clinical practice. In: Current issues in cardiovascular medicine, volume II. Editor: H. Elliot, Martin Dunitz Publishers, London (UK) 1999.
Stroes ESG, Rabelink TJ, Faassen EE. Uncoupling of endothelial nitric Oxide synthase: a molecular basis for atherosclerosis. In: Vascular protection: Molecular mechanisms, novel therapeutic principles and clinical application Editors: Rubanyi GM, Dzau VJ, Cooke JP, Harwoord Academic publishers (UK) 2001.
Stroes ESG, de Groot E. Intermediaire eindpunten voor atherosclerose. In: Leerboek Vasculaire geneeskunde Editors: Buller HR, Kastelein JJP, Stroes ESG. Zuiden communications, 2002 - 2005
Stroes ESG, den Heijer M, Bredie SJ. Atherosclerose, lipiden en homocysteine. In: Nederlands belgisch leerboek Endocrinologie Editors: Wiersinga W, Krenning P.